Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 7/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440421 | 0.98 | PTGES (0.52) | PTGESPTGS2TSHRMAPTLMNA | |
| SCHEMBL1441243 | 0.95 | MAPT (0.52) | PTGESPTGS2MAPTLMNATP53 | |
| SCHEMBL1440737 | 0.92 | MAPT (0.56) | PTGESPTGS2TSHRMAPTLMNA | |
| SCHEMBL1439975 | 0.92 | PTGES (0.48) | PTGESPTGS2TSHRMAPTLMNA | |
| SCHEMBL1441498 | 0.92 | PTGES (0.48) | PTGESPTGS2TSHRMAPTLMNA | |
| SCHEMBL1440323 | 0.92 | MAPT (0.56) | PTGESPTGS2TSHRMAPTLMNA | |
| SCHEMBL1440380 | 0.87 | PTGES (0.58) | PTGESPTGS2TSHRMAPTLMNA | |
| SCHEMBL1440573 | 0.86 | PTGES (0.54) | PTGESPTGS2MAPTLMNATP53 | |
| SCHEMBL1440570 | 0.86 | PTGES (0.54) | PTGESPTGS2MAPTLMNATP53 | |
| SCHEMBL1443417 | 0.84 | TP53 (0.44) | MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |