Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | ALPL | P05186 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536903 | 0.85 | LMNA (0.75) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 | |
| SCHEMBL7532258 | 0.84 | TP53 (0.78) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 | |
| SCHEMBL12368218 | 0.84 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 | |
| SCHEMBL18530465 | 0.82 | SMN1; SMN2 (0.79) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 | |
| SCHEMBL12368214 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 | |
| SCHEMBL12391678 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 | |
| SCHEMBL12368213 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 | |
| SCHEMBL16815088 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2KMT2AALPLLMNAMEN1 | |
| SCHEMBL13852840 | 0.79 | SMN1; SMN2 (0.65) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 | |
| SCHEMBL13853023 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2KMT2AGAAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007112998-A1 | 3-UNSUBSTITUTED N-(ARYL- OR HETEROARVL)-PYRAZOLORI [1,5-A]PYRIMIDINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |