Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ALPL | P05186 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18530465 | 0.91 | SMN1; SMN2 (0.79) | LMNASMN1; SMN2KMT2AMEN1ALOX12 | |
| SCHEMBL95715 | 0.86 | SMN1; SMN2 (0.71) | LMNASMN1; SMN2KMT2AMEN1ALOX12 | |
| SCHEMBL7535714 | 0.86 | SMN1; SMN2 (0.72) | LMNASMN1; SMN2KMT2AMEN1ALOX12 | |
| SCHEMBL5962533 | 0.86 | SMN1; SMN2 (0.71) | LMNASMN1; SMN2KMT2AMEN1ALOX12 | |
| SCHEMBL7529463 | 0.86 | TP53 (0.80) | LMNASMN1; SMN2KMT2AMEN1ALOX12 | |
| SCHEMBL7528115 | 0.86 | SMN1; SMN2 (0.72) | LMNASMN1; SMN2KMT2AMEN1ALOX12 | |
| SCHEMBL14403263 | 0.85 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2KMT2AMEN1ALOX12 | |
| SCHEMBL23846500 | 0.84 | LMNA (0.73) | LMNASMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL21761109 | 0.84 | LMNA (0.73) | LMNASMN1; SMN2KMT2AMEN1ALOX12 | |
| SCHEMBL7571589 | 0.84 | LMNA (0.73) | LMNASMN1; SMN2KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183393-A1 | Inhibitors of Rho C | ICONIX PHARMACEUTICALS INC. | 2002-12-05 | — | — | US | disclosed |
| WO-2002022565-A1 | INHIBITORS OF RHO C | ICONIX PHARMACEUTICALS, INC. (US) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183393-A1 | Inhibitors of Rho C | RHOC, ROCK1, RHOA | LMNA 2037/4885SMN1; SMN2 2961/4885KMT2A 3479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.