Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18717220 | 0.84 | MKNK1 (0.53) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL20180337 | 0.79 | HSD17B10 (0.47) | MEN1PIK3CAPI4KAPI4KBALDH1A1 | |
| SCHEMBL77876 | 0.79 | MKNK1 (0.63) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL30516501 | 0.79 | MKNK1 (0.63) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL12458074 | 0.77 | ERN1 (0.48) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL22497670 | 0.76 | MKNK1 (0.65) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL29898220 | 0.75 | ALDH1A1 (0.61) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL28857629 | 0.75 | ALDH1A1 (0.61) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL20409462 | 0.75 | MKNK1 (0.58) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL11371958 | 0.75 | MKNK1 (0.62) | MKNK1MKNK2MEN1PSIP1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |