Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14404118 | 0.77 | MKNK1 (0.53) | ERN1CYP2A6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19204156 | 0.72 | CYP1A2 (0.59) | ALDH1A1CYP1A2CYP3A4CLK4 | |
| SCHEMBL24385121 | 0.71 | HTR6 (0.49) | ERN1CYP2A6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL15800497 | 0.69 | CYP2A6 (0.60) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL30620885 | 0.67 | CYP2A6 (0.79) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL17951830 | 0.67 | CYP2A6 (0.79) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL12103445 | 0.67 | CYP2A6 (0.79) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL29360677 | 0.67 | CYP2A6 (0.88) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL13907273 | 0.67 | CYP2A6 (0.88) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL24534338 | 0.67 | CYP2A6 (0.88) | CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | ERN1 2082/4885CYP2A6 75/4885ALDH1A1 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.