Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11888071 | 0.85 | EGFR (0.40) | EGFRMEN1APAF1NPC1POLB | |
| SCHEMBL12233431 | 0.80 | TP53 (0.31) | ARMAPT | |
| SCHEMBL12257076 | 0.80 | AR (0.38) | EGFRPOLBARMAPT | |
| SCHEMBL13744148 | 0.79 | ALDH1A1 (0.50) | MEN1NPC1POLBBLMKMT2A | |
| SCHEMBL11307021 | 0.78 | KDM4E (0.51) | MEN1NPC1POLBPABPC1KMT2A | |
| SCHEMBL14556766 | 0.74 | BACE1 (0.38) | MEN1POLBKMT2AAR | |
| SCHEMBL13715799 | 0.74 | KIF11 (0.43) | EGFRMEN1NPC1KMT2AMAPT | |
| SCHEMBL2611832 | 0.74 | KMT2A (0.43) | NPC1POLBKMT2AMAPT | |
| SCHEMBL29424103 | 0.74 | KMT2A (0.43) | NPC1POLBKMT2AMAPT | |
| SCHEMBL29424102 | 0.74 | KMT2A (0.43) | NPC1POLBKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136935-A1 | 2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS | UNIVERSITY OF HAWAII (US) | 2018-07-26 | — | — | WO | disclosed |
| WO-2007118602-A1 | COMPOUNDS FOR TREATING PULMONARY HYPERTENSION | BAYER HEALTHCARE AG (DE) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007085540-A1 | 1H-INDAZ0L-4-YL-2 , 4-PYRIMIDINEDIAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007028445-A1 | 6-INDOLYL-4-YL-AMINO-5-HALOGENO-2-PYRIMIDINYL-AMINO DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | WO | disclosed |