Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10214813 | 0.87 | AURKA (0.47) | NPC1LMNARAB9AAURKAMAPT | |
| SCHEMBL957961 | 0.73 | NPC1 (0.52) | NPC1LMNARAB9AAURKAMAPT | |
| SCHEMBL760762 | 0.72 | KMT2A (0.47) | NPC1RAB9AALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL762095 | 0.71 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2L3MBTL1ADORA3SNCA | |
| SCHEMBL9943544 | 0.70 | IRAK4 (0.49) | NPC1LMNARAB9AMAPTSMN1; SMN2 | |
| SCHEMBL23514479 | 0.69 | KMT2A (0.47) | NPC1RAB9AALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL953675 | 0.69 | AKR1C3 (0.48) | NPC1AURKASMN1; SMN2L3MBTL1ADORA3 | |
| SCHEMBL23514478 | 0.69 | L3MBTL1 (0.43) | NPC1LMNARAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL30050915 | 0.66 | PARP1 (0.52) | NPC1RAB9AL3MBTL1ADORA3SNCA | |
| SCHEMBL2579724 | 0.66 | KLKB1 (0.43) | NPC1RAB9AALDH1A1L3MBTL1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |