Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 15/20 | 0.52 |
| ▸ | NOS1 | P29475 | 15/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 9/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2262457 | 0.91 | NOS3 (0.51) | NOS3NOS1OPRM1NOS2 | |
| SCHEMBL12391672 | 0.91 | NOS3 (0.54) | NOS3NOS1OPRM1NOS2KCNH2 | |
| SCHEMBL2262112 | 0.91 | NOS3 (0.62) | NOS3NOS1OPRM1NOS2KCNH2 | |
| SCHEMBL1122087 | 0.84 | NOS3 (0.69) | NOS3NOS1OPRM1NOS2KCNH2 | |
| SCHEMBL2263080 | 0.82 | NOS3 (0.49) | NOS3NOS1OPRM1NOS2KCNH2 | |
| SCHEMBL14388882 | 0.80 | NOS3 (0.46) | NOS3NOS1OPRM1NOS2KCNH2 | |
| SCHEMBL1593998 | 0.79 | OPRM1 (0.71) | NOS3NOS1OPRM1NOS2 | |
| SCHEMBL14618254 | 0.78 | OPRM1 (0.62) | NOS3NOS1OPRM1NOS2 | |
| SCHEMBL15178523 | 0.77 | NOS3 (0.36) | NOS3NOS1OPRM1 | |
| SCHEMBL12367461 | 0.77 | SMN1; SMN2 (0.38) | NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007118314-A1 | 1,5 AND 3,6- SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2007-10-25 | — | — | WO | disclosed |