Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.58 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144414 | 0.86 | KDR (0.61) | CHEK1KDR | |
| SCHEMBL5076112 | 0.83 | CHEK1 (0.71) | CHEK1KDR | |
| SCHEMBL5076105 | 0.82 | CHEK1 (0.65) | CHEK1KDR | |
| SCHEMBL143389 | 0.82 | CHEK1 (0.69) | CHEK1KDR | |
| SCHEMBL142580 | 0.82 | CHEK1 (0.59) | CHEK1KDR | |
| SCHEMBL5076111 | 0.81 | CHEK1 (0.66) | CHEK1KDR | |
| SCHEMBL142109 | 0.81 | CHEK1 (0.54) | CHEK1KDR | |
| SCHEMBL5078790 | 0.80 | CHEK1 (0.67) | CHEK1KDR | |
| SCHEMBL5082483 | 0.80 | CHEK1 (0.70) | CHEK1KDR | |
| SCHEMBL5079333 | 0.80 | CHEK1 (0.64) | CHEK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6927293-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2005-08-09 | — | — | US | claimed |
| US-20040192725-A1 | Tyrosine kinase inhibitors | MERCK & CO., INC. | 2004-09-30 | — | — | US | claimed |
| WO-2003020276-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-03-13 | — | — | WO | claimed |
| US-20140221455-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | Verva Pharmaceuticals, Inc. (AU) | 2014-08-07 | — | — | US | disclosed |
| US-20120059047-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | VERVA PHARMACEUTICALS PTY LTD (AU) | 2012-03-08 | — | — | US | disclosed |
| US-20050282733-A1 | Differentiation modulating agents and uses therefor | VERVA PHARMACEUTICALS PTY LTD (AU) | 2005-12-22 | — | — | US | disclosed |
| US-6927293-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2005-08-09 | — | — | US | disclosed |
| US-20040192725-A1 | Tyrosine kinase inhibitors | MERCK & CO., INC. | 2004-09-30 | — | — | US | disclosed |
| WO-2003020276-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192725-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | CHEK1 499/4885KDR 5/4885PARP1 2637/4885 |
| US-20120059047-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | FGF1, FABP4, FGF2 | CHEK1 3154/4885KDR 1077/4885PARP1 2973/4885 |
| US-20050282733-A1 | Differentiation modulating agents and uses therefor | FGF1, FABP4, FGF2 | CHEK1 3154/4885KDR 1077/4885PARP1 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.