Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037149 | 0.86 | MEN1 (0.57) | GCGRL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL13739786 | 0.86 | MEN1 (0.55) | L3MBTL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL13963393 | 0.85 | ADORA1 (0.54) | GCGRL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL2643615 | 0.84 | MEN1 (0.53) | L3MBTL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2643572 | 0.83 | MEN1 (0.56) | L3MBTL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2644838 | 0.83 | MEN1 (0.55) | L3MBTL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3421633 | 0.82 | ALDH1A1 (0.62) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL2643643 | 0.81 | MEN1 (0.54) | L3MBTL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3423870 | 0.80 | MAPT (0.66) | L3MBTL1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28453179 | 0.79 | STAT3 (0.68) | L3MBTL1MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273876-B2 | Substituted bicylic thiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2007-09-25 | — | — | US | disclosed |
| US-7273876-B2 | Substituted bicylic thiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2007-09-25 | — | — | US | disclosed |