Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16402703 | 0.83 | SMN1; SMN2 (0.44) | CYP11B1CYP11B2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL153089 | 0.80 | CYP11B1 (0.56) | CYP11B1CYP11B2HDAC1HDAC2LMNA | |
| SCHEMBL13437308 | 0.79 | ALDH1A1 (0.50) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12890736 | 0.79 | CYP11B1 (0.49) | CYP11B1CYP11B2HDAC1HDAC2LMNA | |
| SCHEMBL2095827 | 0.78 | CYP11B1 (0.54) | CYP11B1CYP11B2HDAC1HDAC2LMNA | |
| SCHEMBL28296261 | 0.78 | CYP11B1 (0.41) | CYP11B1CYP11B2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL20011457 | 0.78 | CYP11B1 (0.55) | CYP11B1CYP11B2HDAC1HDAC2LMNA | |
| SCHEMBL12844399 | 0.77 | CYP11B1 (0.54) | CYP11B1CYP11B2HDAC1HDAC2LMNA | |
| SCHEMBL2226354 | 0.77 | CYP11B1 (0.53) | CYP11B1CYP11B2HDAC1HDAC2LMNA | |
| SCHEMBL6973608 | 0.77 | CYP11B1 (0.53) | CYP11B1CYP11B2HDAC1HDAC2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273876-B2 | Substituted bicylic thiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2007-09-25 | — | — | US | disclosed |