Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.44 |
| ▸ | MET | P08581 | 4/20 | 0.44 |
| ▸ | FLT1 | P17948 | 14/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240438 | 0.92 | KDR (0.46) | KDRMETFLT1AURKALCK | |
| SCHEMBL5240496 | 0.89 | KDR (0.45) | KDRMETFLT1 | |
| SCHEMBL14409832 | 0.88 | KDR (0.45) | KDRMETFLT1 | |
| SCHEMBL5888652 | 0.88 | KDR (0.49) | KDRMETFLT1 | |
| SCHEMBL5244749 | 0.87 | KDR (0.47) | KDRMETFLT1 | |
| SCHEMBL5240238 | 0.86 | KDR (0.45) | KDRMETFLT1 | |
| SCHEMBL5243763 | 0.85 | KDR (0.45) | KDRMETFLT1 | |
| SCHEMBL14409901 | 0.85 | KDR (0.44) | KDRMETFLT1AURKALCK | |
| SCHEMBL5242184 | 0.84 | KDR (0.46) | KDRMETFLT1 | |
| SCHEMBL5244328 | 0.83 | MET (0.49) | KDRMETFLT1AURKALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515975-B1 | BENZOFUSED HETEROARYL AMIDE DERIVATIVES OF THIENOPYRIDINES USEFUL AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME, AND METHODS FOR THEIR USE | PFIZER (US) | 2007-09-19 | — | — | EP | disclosed |