SCHEMBL14412271

SCHEMBL14412271

NNC(=O)c1ccc(-c2cc(C(F)(F)F)nn2CCN2CCCCC2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 8/20 0.54
HDAC1 Q13547 7/20 0.54
HDAC6 Q9UBN7 7/20 0.54
HDAC3 O15379 6/20 0.54
HDAC7 Q8WUI4 6/20 0.54
HDAC2 Q92769 6/20 0.54
HDAC8 Q9BY41 6/20 0.54
HDAC5 Q9UQL6 6/20 0.54
HDAC9 Q9UKV0 4/20 0.54
NCOR2 Q9Y618 4/20 0.54
HDAC10 Q969S8 3/20 0.54
HDAC11 Q96DB2 3/20 0.54
CHRNB2 P17787 1/20 0.48
CHRNB4 P30926 1/20 0.48
CHRNA3 P32297 1/20 0.48
CHRNA4 P43681 1/20 0.48
SIGMAR1 Q99720 2/20 0.41
CD274 Q9NZQ7 1/20 0.40
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1594298 0.75 CYP3A4 (0.48) HDAC4HDAC1HDAC6HDAC3HDAC7
SCHEMBL9966074 0.74 HDAC4 (0.62) HDAC4HDAC1HDAC6HDAC3HDAC7
SCHEMBL3471829 0.71 CHRNB2 (0.52) HDAC4HDAC1HDAC6HDAC3HDAC7
SCHEMBL3474382 0.71 PTGS2 (0.42) HDAC4HDAC1HDAC6HDAC3HDAC7
SCHEMBL9966078 0.71 HDAC6 (0.59) HDAC4HDAC1HDAC6HDAC3HDAC7
SCHEMBL22637352 0.70 GRN (0.44) CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1
SCHEMBL28534046 0.70 HDAC1 (1.00) HDAC4HDAC1HDAC6HDAC3HDAC7
SCHEMBL3474545 0.70 CHRNB2 (0.51) HDAC4HDAC1HDAC6HDAC3HDAC7
SCHEMBL9966110 0.68 HPGD (0.53) HDAC4HDAC1HDAC6HDAC3HDAC7
SCHEMBL1594984 0.68 HDAC4 (0.53) HDAC4HDAC1HDAC6HDAC3HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007100851-A1 THERAPEUTIC COMPOUNDS HELICON THERAPEUTICS, INC. (US) 2007-09-07 WO disclosed