Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986107 | 0.82 | EHMT2 (0.46) | MAPTKMT2APOLBNPSR1 | |
| SCHEMBL8705856 | 0.80 | KMT2A (0.42) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL13986145 | 0.76 | PDE4A (0.55) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27952135 | 0.74 | REV1 (0.50) | MAPTALDH1A1HSD17B10KDM4CSIRT2 | |
| SCHEMBL14412777 | 0.74 | PDE4A (0.54) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27952036 | 0.73 | HSD17B10 (0.53) | MAPK1HTTMAPTALDH1A1HSD17B10 | |
| SCHEMBL27939972 | 0.73 | HSD17B10 (0.53) | MAPK1HTTMAPTALDH1A1HSD17B10 | |
| SCHEMBL11373957 | 0.73 | MAPK1 (0.64) | MAPK1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27940072 | 0.73 | SIGMAR1 (0.52) | MAPK1SIGMAR1ALDH1A1HSD17B10KMT2A | |
| SCHEMBL27940132 | 0.73 | SIGMAR1 (0.52) | MAPK1SIGMAR1ALDH1A1HSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070208181-A1 | BENZYLATED PDE4 INHIBITORS | INFLAZYME PHARMACEUTICALS LTD. (CA) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208181-A1 | BENZYLATED PDE4 INHIBITORS | PDE4B, PDE4A, PDE3B | MAPK1 1008/4885PDE4A 2/4885PDE4B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.