Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.45 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809777 | 1.00 | HSD11B1 (0.45) | HSD11B1SPRHSD17B10ALDH1A1MEN1 | |
| SCHEMBL14412803 | 0.96 | HSD11B1 (0.43) | HSD11B1SPRHSD17B10ALDH1A1MEN1 | |
| SCHEMBL14412815 | 0.96 | HSD11B1 (0.43) | HSD11B1SPRHSD17B10ALDH1A1MEN1 | |
| SCHEMBL12809449 | 0.87 | HSD11B1 (0.45) | HSD11B1SPRHSD17B10ALDH1A1MEN1 | |
| SCHEMBL12809739 | 0.85 | HSD11B1 (0.44) | HSD11B1SPRHSD17B10ALDH1A1MEN1 | |
| SCHEMBL12809450 | 0.85 | HSD11B1 (0.44) | HSD11B1SPRHSD17B10ALDH1A1MEN1 | |
| SCHEMBL1406856 | 0.84 | HSD11B1 (0.61) | HSD11B1HTTLMNA | |
| SCHEMBL14412570 | 0.83 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL14412582 | 0.80 | HTT (0.36) | HSD11B1HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL12809716 | 0.80 | HSD11B1 (0.43) | HSD11B1SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |