Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809450 | 0.87 | HSD11B1 (0.44) | HSD11B1LMNAHTTSPRHSD17B10 | |
| SCHEMBL12809739 | 0.87 | HSD11B1 (0.44) | HSD11B1LMNAHTTSPRHSD17B10 | |
| SCHEMBL14412974 | 0.87 | HSD11B1 (0.45) | HSD11B1LMNAHTTSPRHSD17B10 | |
| SCHEMBL12809777 | 0.87 | HSD11B1 (0.45) | HSD11B1LMNAHTTSPRHSD17B10 | |
| SCHEMBL12809747 | 0.86 | HTT (0.49) | HSD11B1LMNAHTTHSD17B10ALDH1A1 | |
| SCHEMBL14412803 | 0.83 | HSD11B1 (0.43) | HSD11B1SPRHSD17B10ALDH1A1MEN1 | |
| SCHEMBL14412815 | 0.83 | HSD11B1 (0.43) | HSD11B1SPRHSD17B10ALDH1A1MEN1 | |
| SCHEMBL1406622 | 0.83 | HSD11B1 (0.62) | HSD11B1LMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL12809710 | 0.80 | HTT (0.40) | HSD11B1LMNAHTTHSD17B10ALDH1A1 | |
| SCHEMBL12809567 | 0.80 | LMNA (0.40) | HSD11B1LMNAHTTHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |