Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PTGES | O14684 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440810 | 1.00 | TP53 (0.48) | TP53LMNASMOMAPTPTGES | |
| SCHEMBL1440369 | 0.92 | MAPT (0.52) | TP53LMNASMOMAPTPTGES | |
| SCHEMBL1440309 | 0.92 | MAPT (0.52) | TP53LMNASMOMAPTPTGES | |
| SCHEMBL1440367 | 0.92 | MAPT (0.52) | TP53LMNASMOMAPTPTGES | |
| SCHEMBL1440314 | 0.92 | MAPT (0.52) | TP53LMNASMOMAPTPTGES | |
| SCHEMBL1440573 | 0.88 | PTGES (0.54) | TP53LMNASMOMAPTPTGES | |
| SCHEMBL1440570 | 0.88 | PTGES (0.54) | TP53LMNASMOMAPTPTGES | |
| SCHEMBL1440380 | 0.86 | PTGES (0.58) | TP53LMNAMAPTPTGESTSHR | |
| SCHEMBL29767208 | 0.84 | TP53 (0.57) | TP53LMNAMAPTPTGESPOLB | |
| SCHEMBL1440737 | 0.79 | MAPT (0.56) | TP53LMNAMAPTPTGESTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012117062-A1 | PIPERIDINYL BENZOIMIDAZOLE DERIVATIVES AS MPGES-1 INIHIBITORS | NOVASAID AB (SE) | 2012-09-07 | — | — | WO | disclosed |
| EP-2495244-A1 | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors | NovaSaid AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| EP-2495244-A1 | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors | NovaSaid AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |