Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 7/20 | 0.54 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440570 | 1.00 | PTGES (0.54) | PTGESSMOMAPTLMNATP53 | |
| SCHEMBL1440314 | 0.92 | MAPT (0.52) | PTGESSMOMAPTLMNATP53 | |
| SCHEMBL1440309 | 0.92 | MAPT (0.52) | PTGESSMOMAPTLMNATP53 | |
| SCHEMBL1440369 | 0.92 | MAPT (0.52) | PTGESSMOMAPTLMNATP53 | |
| SCHEMBL1440367 | 0.92 | MAPT (0.52) | PTGESSMOMAPTLMNATP53 | |
| SCHEMBL1441243 | 0.88 | MAPT (0.52) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL1440810 | 0.88 | TP53 (0.48) | PTGESSMOMAPTLMNATP53 | |
| SCHEMBL1441508 | 0.88 | TP53 (0.48) | PTGESSMOMAPTLMNATP53 | |
| SCHEMBL1440421 | 0.86 | PTGES (0.52) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL1440054 | 0.86 | PTGES (0.52) | PTGESMAPTLMNATP53PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012117062-A1 | PIPERIDINYL BENZOIMIDAZOLE DERIVATIVES AS MPGES-1 INIHIBITORS | NOVASAID AB (SE) | 2012-09-07 | — | — | WO | disclosed |
| EP-2495244-A1 | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors | NovaSaid AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |