Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.64 |
| ▸ | DRD3 | P35462 | 7/20 | 0.55 |
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14415499 | 0.89 | HTR6 (0.62) | HTR6DRD3DRD2HRH3BCHE | |
| SCHEMBL13711071 | 0.81 | HTR6 (0.66) | HTR6DRD3DRD2HRH3BCHE | |
| SCHEMBL5960063 | 0.77 | HTR6 (0.62) | HTR6DRD3DRD2HRH3SMN1; SMN2 | |
| SCHEMBL5106715 | 0.75 | HRH3 (0.67) | HTR6DRD3DRD2HRH3KDM4E | |
| SCHEMBL5758025 | 0.73 | HTR6 (0.64) | HTR6DRD3DRD2BCHEHRH1 | |
| SCHEMBL5097432 | 0.73 | HRH3 (0.70) | HRH3KDM4E | |
| Hydrochloric Acid SCHEMBL4082476 | 0.72 | HTR6 (0.63) | HTR6DRD3DRD2BCHEHRH1 | |
| SCHEMBL6109901 | 0.72 | HRH3 (0.90) | HTR6DRD3DRD2HRH3HRH1 | |
| SCHEMBL26437040 | 0.72 | NPC1 (0.54) | DRD3DRD2HRH3BCHEKDM4E | |
| SCHEMBL5242307 | 0.72 | HTR6 (0.65) | HTR6DRD3DRD2BCHEHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271180-B2 | 1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-09-18 | — | — | US | disclosed |