Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.62 |
| ▸ | DRD3 | P35462 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | OXTR | P30559 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14415236 | 0.89 | HTR6 (0.64) | HTR6DRD3DRD2HRH3KDM4E | |
| SCHEMBL13711071 | 0.79 | HTR6 (0.66) | HTR6DRD3DRD2HRH3BCHE | |
| SCHEMBL5960063 | 0.75 | HTR6 (0.62) | HTR6DRD3DRD2HRH3 | |
| SCHEMBL5759716 | 0.74 | HTR6 (0.62) | HTR6DRD2BCHE | |
| Hydrochloric Acid SCHEMBL4077364 | 0.74 | HTR6 (0.61) | HTR6DRD2BCHE | |
| SCHEMBL7007212 | 0.69 | POLB (0.56) | POLBKDM4EDRD1DRD4DRD5 | |
| SCHEMBL14578233 | 0.69 | DRD1 (0.65) | POLBKDM4EDRD1DRD4DRD5 | |
| SCHEMBL4649197 | 0.69 | HTR2A (0.49) | HTR6DRD2POLBKDM4EDRD1 | |
| SCHEMBL14302660 | 0.68 | HTR6 (0.76) | HTR6DRD3DRD2HRH3 | |
| SCHEMBL6042440 | 0.68 | POLB (0.68) | DRD3DRD2POLBKDM4EDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271180-B2 | 1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-09-18 | — | — | US | disclosed |