Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14310727 | 1.00 | SIRT2 (0.50) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| SCHEMBL236067 | 0.91 | SIRT5 (0.51) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| SCHEMBL14264834 | 0.91 | SIRT5 (0.51) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| SCHEMBL14286269 | 0.91 | SIRT5 (0.51) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| Hydrochloric Acid SCHEMBL3503087 | 0.90 | SIRT5 (0.51) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| SCHEMBL2268022 | 0.84 | SIRT5 (0.57) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| Hydrochloric Acid SCHEMBL10884941 | 0.84 | SIRT5 (0.56) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| Hydrochloric Acid SCHEMBL10943848 | 0.84 | SIRT5 (0.56) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| SCHEMBL1529286 | 0.84 | SIRT2 (0.48) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL17289476 | 0.83 | SIRT5 (0.55) | SIRT2SIRT1SIRT5SIRT3TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273610-B2 | Endotheliase-2 ligands | DYAX CORP. (US) | 2007-09-25 | — | — | US | disclosed |