Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417816 | 0.88 | POLB (0.38) | L3MBTL1GAAPKMALDH1A1KDM4E | |
| SCHEMBL14417825 | 0.84 | L3MBTL1 (0.44) | L3MBTL1GAAPKMALDH1A1KDM4E | |
| SCHEMBL23555007 | 0.79 | L3MBTL1 (0.56) | L3MBTL1GAAPKMALDH1A1KDM4E | |
| SCHEMBL31030375 | 0.74 | L3MBTL1 (0.49) | L3MBTL1GAAPKMALDH1A1KDM4E | |
| SCHEMBL178417 | 0.74 | L3MBTL1 (0.49) | L3MBTL1GAAPKMALDH1A1KDM4E | |
| SCHEMBL3782563 | 0.73 | CYP2D6 (0.44) | ALDH1A1HSD17B10TSHRUSP2SMN1; SMN2 | |
| SCHEMBL4277869 | 0.73 | L3MBTL1 (0.47) | L3MBTL1GAAPKMALDH1A1KDM4E | |
| SCHEMBL24465579 | 0.72 | L3MBTL1 (0.44) | L3MBTL1GAAPKMALDH1A1KDM4E | |
| SCHEMBL1820360 | 0.72 | SLC6A9 (0.44) | SLC6A9 | |
| SCHEMBL10192197 | 0.71 | L3MBTL1 (0.50) | L3MBTL1GAAPKMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268150-B2 | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-11 | — | — | US | disclosed |
| US-7268150-B2 | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-11 | — | — | US | disclosed |