Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 4/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.37 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12121529 | 0.93 | CCR1 (0.56) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL13617244 | 0.92 | CCR1 (0.53) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL15478373 | 0.91 | CCR1 (0.54) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL14419980 | 0.91 | CCR1 (0.54) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL10287667 | 0.91 | CCR1 (0.54) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL7210849 | 0.90 | CCR1 (0.63) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL7210846 | 0.90 | CCR1 (0.63) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL7206597 | 0.90 | CCR1 (0.53) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL7206591 | 0.90 | CCR1 (0.53) | CCR1CHRM2CCR5ALDH1A1MEN1 | |
| SCHEMBL10287524 | 0.89 | CCR1 (0.54) | CCR1CHRM2CCR5ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |