Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | BAD | Q92934 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1262244 | 0.89 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2RAB9AMEN1LMNA | |
| SCHEMBL5428824 | 0.87 | CES2 (0.54) | MAPTSMN1; SMN2CA1CA2LMNA | |
| SCHEMBL3282811 | 0.87 | CES2 (0.54) | MAPTCA1CA2RAB9AMEN1 | |
| SCHEMBL7639339 | 0.80 | CHEK2 (0.57) | GSK3B | |
| SCHEMBL80529 | 0.79 | MAPT (0.60) | MAPTHSD17B1CA12CA1CA2 | |
| SCHEMBL5842596 | 0.79 | TSHR (0.71) | SMN1; SMN2BCL2L1BADCA12CA1 | |
| SCHEMBL27146 | 0.77 | CES2 (0.62) | MAPTCA1CA2RAB9AMEN1 | |
| SCHEMBL513187 | 0.77 | TPMT (0.59) | CA1CA2TP53TSHRPTPN1 | |
| SCHEMBL1259812 | 0.77 | CES2 (0.62) | MAPTBCL2L1BADCA1CA2 | |
| SCHEMBL1259416 | 0.77 | CES2 (0.62) | MAPTCA1CA2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011028596-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-03-10 | — | — | WO | disclosed |