Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.54 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.51 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.51 |
| ▸ | PPM1D | O15297 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15761746 | 0.85 | HIF1A (0.60) | LOXL2HIF1ACYP4F2CYP4A11SLC7A5 | |
| SCHEMBL31237125 | 0.85 | MRGPRX4 (0.57) | LOXL2HIF1ACYP4F2CYP4A11SLC7A5 | |
| SCHEMBL1180032 | 0.85 | LOXL2 (0.53) | LOXL2HIF1ACYP4F2CYP4A11SLC7A5 | |
| SCHEMBL14420823 | 0.85 | MRGPRX4 (0.59) | HIF1APPM1DHDAC1HDAC4MEF2D | |
| SCHEMBL15761754 | 0.84 | HIF1A (0.58) | LOXL2HIF1ACYP4F2CYP4A11SLC7A5 | |
| SCHEMBL15755934 | 0.84 | HIF1A (0.58) | LOXL2HIF1ACYP4F2CYP4A11SLC7A5 | |
| SCHEMBL8005946 | 0.83 | HIF1A (0.53) | LOXL2HIF1ACYP4F2CYP4A11SLC7A5 | |
| SCHEMBL23286785 | 0.82 | CA1 (0.61) | LOXL2HIF1ACA1CA2HDAC1 | |
| SCHEMBL15687652 | 0.82 | CA1 (0.61) | LOXL2HIF1ASLC7A5PPM1DCA1 | |
| SCHEMBL26436295 | 0.82 | LOXL2 (0.60) | LOXL2HIF1ACYP4F2CYP4A11SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |