Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.73 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783215 | 0.87 | PIM1 (0.78) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL4739564 | 0.86 | PIM1 (0.77) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL11750772 | 0.86 | PIM1 (0.75) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL11539600 | 0.84 | HSD17B10 (0.74) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL4782912 | 0.79 | HPGD (0.55) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL32665352 | 0.77 | MAPT (0.57) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL5619103 | 0.76 | PIM1 (0.67) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL4781880 | 0.76 | PIM1 (0.67) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL5618450 | 0.76 | PIM1 (0.55) | PIM1HSD17B10HTTSMN1; SMN2HPGD | |
| SCHEMBL4784537 | 0.76 | HPGD (0.48) | PIM1HSD17B10HTTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268136-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268136-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |