Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | APAF1 | O14727 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CDC7 | O00311 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422698 | 0.87 | PIM1 (0.76) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL11750772 | 0.87 | PIM1 (0.75) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL11751799 | 0.86 | PIM1 (0.79) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL11539600 | 0.85 | HSD17B10 (0.74) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL4784322 | 0.80 | HSD17B10 (0.53) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL4781880 | 0.78 | PIM1 (0.67) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL32665000 | 0.78 | ALDH1A1 (0.50) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL5619103 | 0.78 | PIM1 (0.67) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL5618927 | 0.77 | PIM1 (0.63) | PIM1HSD17B10HTTSMN1; SMN2KDM4E | |
| SCHEMBL5618794 | 0.77 | DPP4 (0.69) | PIM1HSD17B10HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008069500-A1 | TRIAZOLOPYRIDAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST ACETYL-COA CARBOXYLASE | AMOREPACIFIC CORPORATION (KR) | 2008-06-12 | — | — | WO | claimed |
| WO-2008069500-A1 | TRIAZOLOPYRIDAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST ACETYL-COA CARBOXYLASE | AMOREPACIFIC CORPORATION (KR) | 2008-06-12 | — | — | WO | disclosed |