Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32665179 | 0.79 | HPGD (0.54) | HPGDALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14422698 | 0.79 | PIM1 (0.76) | HPGDALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4739564 | 0.77 | PIM1 (0.77) | HPGDALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL32665352 | 0.73 | MAPT (0.57) | HPGDALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL32665000 | 0.72 | ALDH1A1 (0.50) | HPGDALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL32665455 | 0.72 | MAPT (0.49) | HPGDALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL32664934 | 0.72 | ALDH1A1 (0.56) | HPGDALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4783215 | 0.69 | PIM1 (0.78) | HPGDALDH1A1HSD17B10KDM4EKMT2A | |
| SCHEMBL32665005 | 0.69 | ALDH1A1 (0.49) | HPGDALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL26132381 | 0.68 | CNR2 (0.40) | HPGDKDM4EMAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008069500-A1 | TRIAZOLOPYRIDAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST ACETYL-COA CARBOXYLASE | AMOREPACIFIC CORPORATION (KR) | 2008-06-12 | — | — | WO | claimed |
| WO-2008069500-A1 | TRIAZOLOPYRIDAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST ACETYL-COA CARBOXYLASE | AMOREPACIFIC CORPORATION (KR) | 2008-06-12 | — | — | WO | disclosed |