Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | GCK | P35557 | 13/20 | 0.55 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642308 | 1.00 | KCNH2 (0.63) | KCNH2GCKFFAR2SCN5A | |
| SCHEMBL2657479 | 0.89 | KCNH2 (0.79) | KCNH2GCKFFAR2 | |
| SCHEMBL2646819 | 0.89 | KCNH2 (0.79) | KCNH2GCKFFAR2 | |
| SCHEMBL2646354 | 0.89 | KCNH2 (0.79) | KCNH2GCKFFAR2 | |
| SCHEMBL2659231 | 0.88 | KCNH2 (0.64) | KCNH2GCKFFAR2SCN5A | |
| SCHEMBL2646119 | 0.88 | KCNH2 (0.78) | KCNH2GCKFFAR2 | |
| SCHEMBL2642103 | 0.84 | KCNH2 (0.61) | KCNH2GCK | |
| SCHEMBL14423117 | 0.84 | KCNH2 (0.61) | KCNH2GCK | |
| SCHEMBL2642073 | 0.84 | GCK (0.76) | KCNH2GCKFFAR2 | |
| SCHEMBL2659540 | 0.83 | KCNH2 (0.48) | KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1329386-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-01 | — | — | CN | claimed |
| CN-1649859-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | claimed |
| US-7259166-B2 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259166-B2 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| CN-1329386-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-01 | — | — | CN | disclosed |
| EP-1501815-B1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2006-11-22 | — | — | EP | disclosed |
| CN-1649859-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | disclosed |
| WO-2003095438-A9 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-12-23 | — | — | WO | disclosed |
| WO-2003095438-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-20 | — | — | WO | disclosed |