Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 8/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | GCK | P35557 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642305 | 1.00 | FFAR2 (0.62) | FFAR2KCNH2GCKLMNAMEN1 | |
| SCHEMBL2645076 | 0.86 | FFAR2 (0.72) | FFAR2KCNH2GCKMAPT | |
| SCHEMBL2657079 | 0.86 | FFAR2 (0.72) | FFAR2KCNH2GCKMAPT | |
| SCHEMBL2645075 | 0.86 | FFAR2 (0.72) | FFAR2KCNH2GCKMAPT | |
| SCHEMBL2642385 | 0.86 | FFAR2 (0.56) | FFAR2KCNH2GCKMAPTCYP3A4 | |
| SCHEMBL2642146 | 0.85 | FFAR2 (0.56) | FFAR2KCNH2GCKLMNAMEN1 | |
| SCHEMBL14423133 | 0.85 | FFAR2 (0.56) | FFAR2KCNH2GCKLMNAMEN1 | |
| SCHEMBL9072697 | 0.84 | FFAR2 (0.66) | FFAR2KCNH2GCKLMNAMEN1 | |
| SCHEMBL2642177 | 0.84 | FFAR2 (0.66) | FFAR2KCNH2GCKLMNAMEN1 | |
| SCHEMBL2651266 | 0.84 | FFAR2 (0.52) | FFAR2KCNH2GCKLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259166-B2 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259166-B2 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| EP-1501815-B1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2006-11-22 | — | — | EP | disclosed |
| WO-2003095438-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-20 | — | — | WO | disclosed |