SCHEMBL14423966

SCHEMBL14423966

CC(C)(C)OC(=O)CSC(N)=S

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.36
CCNB2 O95067 1/20 0.33
CCNE2 O96020 1/20 0.33
CDK1 P06493 1/20 0.33
CDK4 P11802 1/20 0.33
CCNB1 P14635 1/20 0.33
CCND1 P24385 1/20 0.33
CCNE1 P24864 1/20 0.33
CDK2 P24941 1/20 0.33
CCNB3 Q8WWL7 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
ALDH1A1 P00352 1/20 0.31
GLA P06280 1/20 0.31
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12835064 0.82 CCNB2 (0.37) CYP1A2CCNB2CCNE2CDK1CDK4
SCHEMBL13013362 0.82 ALDH1A1 (0.34) CYP1A2CCNB2CCNE2CDK1CDK4
SCHEMBL3184120 0.80 CYP2C19 (0.48) CYP1A2CCNB2CCNE2CDK1CDK4
Bromide SCHEMBL3184112 0.78 CYP2C19 (0.47) CYP1A2CCNB2CCNE2CDK1CDK4
SCHEMBL10198756 0.77
SCHEMBL2502740 0.77 CCNB2 (0.39) CYP1A2CCNB2CCNE2CDK1CDK4
SCHEMBL2445178 0.76 ALDH1A1 (0.59) CYP1A2HDAC3HDAC1HDAC2HDAC8
SCHEMBL28498899 0.74 CYP2D6 (0.33) CYP1A2CCNB2CCNE2CDK1CDK4
SCHEMBL2086711 0.72 DGAT1 (0.37) ALDH1A1MAOAMAOBCYP2D6
SCHEMBL29080281 0.72 CCNB2 (0.37) CYP1A2CCNB2CCNE2CDK1CDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005089764-A9 CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS PTC THERAPEUTICS INC (US) 2007-09-13 WO disclosed