Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 5/20 | 0.45 |
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150784 | 0.84 | NOS1 (0.61) | IDO1NOS1CA12CA1CA2 | |
| SCHEMBL850733 | 0.83 | IDO1 (1.00) | IDO1NOS1 | |
| SCHEMBL12835104 | 0.81 | IDO1 (0.61) | IDO1HTTLOXL2L3MBTL1MAOB | |
| Bromide SCHEMBL31060341 | 0.81 | IDO1 (1.00) | IDO1NOS1 | |
| Hydrochloric Acid SCHEMBL2943843 | 0.81 | IDO1 (0.96) | IDO1NOS1 | |
| SCHEMBL26552953 | 0.78 | NOS1 (0.54) | IDO1LOXL2NOS1RAB9A | |
| SCHEMBL7052090 | 0.77 | IDO1 (0.65) | IDO1HTTLOXL2NOS1L3MBTL1 | |
| SCHEMBL13256344 | 0.76 | IDO1 (0.68) | IDO1HTTLOXL2NOS1L3MBTL1 | |
| SCHEMBL25798168 | 0.76 | IDO1 (0.68) | IDO1HTTLOXL2NOS1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL3421762 | 0.75 | IDO1 (0.66) | IDO1HTTLOXL2NOS1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005089764-A9 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2007-09-13 | — | — | WO | disclosed |