Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8391695 | 0.88 | EPHX1 (0.67) | MAPTEPHX1ALDH1A1EPHX2HTT | |
| SCHEMBL8803832 | 0.81 | KMT2A (0.66) | MAPTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL107176 | 0.81 | MAPT (0.62) | MAPTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL109020 | 0.80 | ALOX15 (0.66) | MAPTRAB9AEPHX1EPHX2ERCC1 | |
| SCHEMBL14012046 | 0.79 | ERCC1 (0.48) | MEN1KMT2ARAB9AALDH1A1ERCC1 | |
| SCHEMBL12988587 | 0.79 | MEN1 (0.76) | MAPTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL11619645 | 0.79 | KMT2A (0.76) | MAPTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL28516814 | 0.79 | MAPT (0.72) | MAPTMEN1KMT2ACYP1A2EPHX1 | |
| SCHEMBL14423982 | 0.78 | EPHX1 (0.79) | MAPTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL14423994 | 0.77 | KMT2A (0.66) | MAPTMEN1KMT2ACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1829876-A1 | NITROGENEOUS TRICYCLIC COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2007-09-05 | — | — | EP | disclosed |