Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levofloxacin Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 1.00 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.98 |
| ▸ | TUBB | P07437 | 7/20 | 0.98 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.98 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.98 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.98 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.98 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.98 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.98 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.98 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.98 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.98 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.98 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.98 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ofloxacin SCHEMBL27542046 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Levofloxacin Anhydrous SCHEMBL15397 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL14163982 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Levofloxacin Anhydrous SCHEMBL515263 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL24373 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL5532921 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL9745243 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Dextrofloxacine SCHEMBL4316947 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Levofloxacin Anhydrous SCHEMBL1442440 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL7719091 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017003909-A2 | CHIRAL SEPARATION AND ANALYSIS BY MOLECULAR PROPELLER EFFECT | CHACHISVILIS MIRIANAS (US) | 2017-01-05 | — | — | WO | disclosed |
| EP-2473170-A1 | USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS | Mpex Pharmaceuticals, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2304425-A1 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | Dynamic Connections, Llc (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2011029059-A1 | USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS | MPEX PHARMACEUTICALS, INC. (US) | 2011-03-10 | — | — | WO | disclosed |
| WO-2009155406-A1 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | DYNAMIC CONNECTIONS, LLC (US) | 2009-12-23 | — | — | WO | disclosed |
| EP-2134697-A2 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | Dynamic Connections, Llc (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008130980-A2 | SEPARATION AND MANIPULATION OF A CHIRAL OBJECT | DYNAMIC CONNECTIONS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |