Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 1.00 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.98 |
| ▸ | TUBB | P07437 | 7/20 | 0.98 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.98 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.98 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.98 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.98 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.98 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.98 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.98 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.98 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.98 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.98 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.98 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ofloxacin SCHEMBL27542046 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Levofloxacin Anhydrous SCHEMBL15397 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL14163982 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Levofloxacin Anhydrous SCHEMBL515263 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL5532921 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL9745243 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Dextrofloxacine SCHEMBL4316947 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Levofloxacin Anhydrous SCHEMBL1442676 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Levofloxacin Anhydrous SCHEMBL1442440 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Ofloxacin SCHEMBL7719091 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 53367 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122076476-A | Yb-BiOI/Ce-MgAl-LDH composite photocatalyst and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122079427-A | Method for degrading organic pollutants by coupling nano-confinement catalytic membrane with micro-nano bubbles | — | 2026-05-26 | — | — | CN | claimed |
| US-20260137558-A1 | OPHTHALMIC DEVICE | Able Tx Ltd. (IL) | 2026-05-21 | — | — | US | claimed |
| EP-4007582-B1 | ANTIBIOTICS IN COMBINATION WITH PHOTODYNAMIC THERAPY FOR USE IN A METHOD OF ENHANCING THE ANTIMICROBIAL ACTION OF SYSTEMICALLY ADMINISTERED ANTIBIOTICS | KOITE HEALTH OY (FI) | 2026-05-20 | — | — | EP | claimed |
| CN-122057085-A | External auditory canal degradable and self-adaptive drug stent with combined drug release in segmented mode and preparation method thereof | 上海交通大学医学院附属瑞金医院 | 2026-05-19 | — | — | CN | claimed |
| CN-122057521-A | LaFeO3@FeIn2S4 photocatalytic material with core-shell structure, preparation method thereof and application thereof in photo-induced persulfate oxidative degradation of tetracycline antibiotics | 中国科学院青海盐湖研究所 | 2026-05-19 | — | — | CN | claimed |
| CN-122036889-A | Cyclized antibacterial peptide CycP-1 of targeted multi-drug resistant klebsiella pneumoniae, composition and application thereof | 湖北江夏实验室 | 2026-05-15 | — | — | CN | claimed |
| CN-122036331-A | Photo-curing alumina-based ceramic slurry and alumina-based ceramic | 西北工业大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122032604-A | Photo-Fenton composite catalyst and preparation method and application thereof | 兰州石化职业技术大学 | 2026-05-15 | — | — | CN | claimed |
| EP-0275515-A1 | Aqueous pharmaceutical composition | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-07-27 | — | — | EP | claimed |
| EP-0272551-A2 | An improved blood bag system incorporating quinolone carboxylic acid derivatives | MILES INC. (US) | 1988-06-29 | — | — | EP | claimed |
| EP-0268223-A2 | Optically active gyrase inhibitors, their preparation and use as antibiotics | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-05-25 | — | — | EP | claimed |
| EP-0255926-A2 | Antibacterial adhesive sheet and method for making it | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-17 | — | — | EP | claimed |
| EP-0228592-A2 | Bone cement | GMT Gesellschaft für medizinische Technik mbH (DE) | 1987-07-15 | — | — | EP | claimed |
| EP-0222814-A1 | USE OF QUINOLONE DERIVATIVES FOR THE TREATMENT OF MYCOPLASMAL PNEUMONIA IN PIGS | BEECHAM GROUP PLC (GB) | 1987-05-27 | — | — | EP | claimed |
| WO-1986006630-A1 | USE OF QUINOLONE DERIVATIVES FOR THE TREATMENT OF MYCOPLASMAL PNEUMONIA IN PIGS | BEECHAM GROUP P.L.C. (GB) | 1986-11-20 | — | — | WO | claimed |
| US-4551456-A | BACTERICIDES | MERCK & CO., INC. (US) | 1985-11-05 | — | — | US | claimed |
| EP-0142426-A2 | Ophthalmic formulation containing norfloxacin and related antibiotics | MERCK & CO. INC. (US) | 1985-05-22 | — | — | EP | claimed |
| US-4382892-A | Benzoxazine derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1983-05-10 | — | — | US | claimed |