SCHEMBL14428397

SCHEMBL14428397

O=Cc1ccc(Sc2ccccc2)cc1NC(=O)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.55
TDP1 Q9NUW8 3/20 0.55
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
PKM P14618 1/20 0.48
GRIK1 P39086 1/20 0.48
ALDH1A1 P00352 3/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
GLA P06280 1/20 0.46
HPGD P15428 3/20 0.42
TP53 P04637 2/20 0.42
HDAC1 Q13547 2/20 0.42
HDAC2 Q92769 2/20 0.42
MDM4 O15151 1/20 0.42
HDAC3 O15379 1/20 0.42
MAPK1 P28482 1/20 0.42
POLB P06746 1/20 0.42
MCL1 Q07820 1/20 0.41
BCL2A1 Q16548 1/20 0.41
KCNK3 O14649 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270296 0.83 TDP1 (0.62) MAPTTDP1MEN1KMT2APKM
SCHEMBL14428398 0.80 MEN1 (0.53) MAPTTDP1MEN1KMT2APKM
SCHEMBL2269880 0.78 KDM4E (0.60) MAPTTDP1MEN1KMT2APKM
SCHEMBL14428165 0.78 HDAC2 (0.66) MAPTTDP1MEN1KMT2APKM
SCHEMBL14428442 0.78 MAPT (0.51) MAPTTDP1MEN1KMT2APKM
SCHEMBL28568397 0.78 KCNMA1 (0.66) MAPTTDP1MEN1KMT2APKM
SCHEMBL14428216 0.78 MAPT (0.58) MAPTTDP1MEN1KMT2APKM
SCHEMBL14090354 0.78 HDAC1 (0.65) MAPTTDP1MEN1KMT2APKM
SCHEMBL14428369 0.77 MEN1 (0.50) MAPTTDP1MEN1KMT2APKM
SCHEMBL30758797 0.77 SNCA (0.59) MAPTTDP1MEN1KMT2APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed