Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 18/20 | 0.60 |
| ▸ | CHUK | O15111 | 16/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | CDK11B | P21127 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.38 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.38 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14432368 | 0.80 | IKBKB (0.57) | IKBKBCHUKMAPK8 | |
| SCHEMBL14431705 | 0.76 | IKBKB (0.65) | IKBKBCHUKMAPK8 | |
| SCHEMBL14431616 | 0.75 | IKBKB (1.00) | IKBKBCHUKERN1RPS6KA4PRKD3 | |
| SCHEMBL14431719 | 0.72 | IKBKB (0.56) | IKBKBCHUKERN1RPS6KA4PRKD3 | |
| SCHEMBL14431587 | 0.72 | HTR1A (0.37) | IKBKBCHUK | |
| SCHEMBL8118265 | 0.63 | MAPK8 (0.73) | IKBKBCHUKMAPK8 | |
| SCHEMBL8103067 | 0.63 | MAPK8 (0.73) | IKBKBMAPK8 | |
| SCHEMBL14431750 | 0.62 | IKBKB (0.78) | IKBKBCHUKERN1RPS6KA4PRKD3 | |
| SCHEMBL11500648 | 0.61 | MAPK8 (0.68) | IKBKBMAPK8 | |
| SCHEMBL3496822 | 0.60 | MAPK8 (0.46) | IKBKBCHUKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490371-B1 | THIOPHENE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL MYERS SQUIBB CO (US) | 2007-08-15 | — | — | EP | disclosed |