Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 2/20 | 0.48 |
| ▸ | RHOA | P61586 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991255 | 0.92 | CACNA1H (0.46) | RHOCRHOAMAOAMAOBCACNA1H | |
| SCHEMBL5233178 | 0.88 | SCN8A (0.55) | TDP1MEN1GAAKMT2AMLYCD | |
| SCHEMBL16152237 | 0.88 | MAOA (0.54) | MAOAMAOBTDP1MEN1GAA | |
| SCHEMBL16152238 | 0.86 | MAOA (0.52) | MAOAMAOBTDP1MEN1GAA | |
| SCHEMBL13887001 | 0.85 | CACNA1H (0.54) | CACNA1HCACNA1BCACNA1CMTORTACR1 | |
| SCHEMBL19300683 | 0.83 | ATM (0.48) | MAOAMAOBCACNA1HCACNA1BCACNA1C | |
| SCHEMBL20127870 | 0.83 | MAOA (0.49) | MAOAMAOBTDP1MEN1GAA | |
| SCHEMBL16151784 | 0.83 | MAOA (0.49) | MAOAMAOBTDP1MEN1GAA | |
| SCHEMBL17513326 | 0.82 | MARS1 (0.51) | MAOAMAOBTDP1MEN1GAA | |
| SCHEMBL16151785 | 0.82 | MAOA (0.48) | MAOAMAOBTDP1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496059-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2007-08-15 | — | — | EP | disclosed |