Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 2/20 | 0.66 |
| ▸ | PGR | P06401 | 3/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | LTK | P29376 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | WDR5 | P61964 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | EDNRB | P24530 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30565215 | 0.91 | PGR (0.75) | HSD17B2PGRBRD4MAP4K4PAK4 | |
| SCHEMBL5730534 | 0.91 | IL1RN (0.66) | HSD17B2PGRBRD4PKMHTR6 | |
| SCHEMBL30408871 | 0.91 | IL1RN (0.66) | HSD17B2PGRBRD4PKMHTR6 | |
| SCHEMBL1403074 | 0.91 | PGR (0.75) | HSD17B2PGRBRD4MAP4K4PAK4 | |
| SCHEMBL13933287 | 0.89 | HSD17B2 (0.66) | HSD17B2PGRBRD4MAP4K4PAK4 | |
| SCHEMBL28271807 | 0.89 | HTR6 (0.71) | HSD17B2PGRBRD4MAP4K4PAK4 | |
| SCHEMBL19065106 | 0.85 | TSHR (0.64) | HSD17B2PGRPKMPTPN2PTPN1 | |
| SCHEMBL22441723 | 0.85 | CDK1 (0.64) | HSD17B2PGRBRD4PKM | |
| SCHEMBL22441816 | 0.83 | HSD17B2 (0.63) | HSD17B2PGRBRD4MAP4K4PAK4 | |
| SCHEMBL22441735 | 0.83 | PGR (0.72) | HSD17B2PGRBRD4KDRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076055-A9 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED INC (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007076055-A2 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED, INC. (US) | 2007-07-05 | — | — | WO | disclosed |