Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.70 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.59 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | CCNH | P51946 | 1/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23493889 | 0.83 | THRB (1.00) | THRBSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL6976941 | 0.81 | HTR6 (0.71) | MEN1KMT2AALDH1A1 | |
| SCHEMBL6971453 | 0.80 | HTR6 (0.66) | — | |
| SCHEMBL6675763 | 0.76 | THRB (0.65) | THRBSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL25010909 | 0.76 | TP53 (0.74) | THRBMEN1KMT2AMAPTTP53 | |
| SCHEMBL24876220 | 0.76 | THRB (0.84) | THRBSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL31679851 | 0.76 | THRB (0.84) | THRBSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL5622490 | 0.75 | HPGD (0.72) | THRBSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL6086804 | 0.75 | MEN1 (0.62) | THRBSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL27424574 | 0.74 | HSD17B2 (0.67) | THRBHSD17B2HSD17B1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076055-A9 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED INC (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007076055-A2 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED, INC. (US) | 2007-07-05 | — | — | WO | disclosed |