Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.46 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382647 | 0.92 | MAPT (0.49) | MAPTPOLBGAACYP26A1RXRA | |
| SCHEMBL10839815 | 0.84 | MAPT (0.51) | MAPTPOLBGAALMNATSHR | |
| SCHEMBL4369358 | 0.82 | ALOX15 (0.44) | MAPTGAACYP26A1RXRACYP26B1 | |
| SCHEMBL5780967 | 0.80 | MAPT (0.42) | MAPTPOLBCYP26A1RXRACYP26B1 | |
| SCHEMBL12022155 | 0.80 | MAPT (0.51) | MAPTPOLBGAACYP26A1RXRA | |
| SCHEMBL11700084 | 0.79 | CYP26A1 (0.41) | CYP26A1RXRACYP26B1RXRBCHEK2 | |
| SCHEMBL5518160 | 0.77 | NPC1 (0.44) | MAPTPOLBALDH1A1CYP2C8SMN1; SMN2 | |
| SCHEMBL11699934 | 0.72 | MAPT (0.45) | MAPTPOLBCYP26A1RXRACYP26B1 | |
| SCHEMBL4385349 | 0.71 | MAPT (0.53) | MAPTPOLBGAALMNATSHR | |
| SCHEMBL1256099 | 0.71 | CHEK2 (0.39) | CYP26A1RXRACYP26B1RXRBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253183-B2 | Method of use of (imidazol-5-yl)methyl-2-quinolinone derivatives to inhibit smooth muscle cell proliferation | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-07 | — | — | US | disclosed |