Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | FADS1 | O60427 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382647 | 0.90 | MAPT (0.49) | ALOX15MAPTTDP1CHEK2RECQL | |
| SCHEMBL12022155 | 0.90 | MAPT (0.51) | ALOX15MAPTTDP1CHEK2PARP1 | |
| SCHEMBL5780967 | 0.90 | MAPT (0.42) | MAPTTDP1CHEK2CYP26A1RXRA | |
| SCHEMBL5518160 | 0.87 | NPC1 (0.44) | MAPTTDP1PARP1KMT2AMEN1 | |
| SCHEMBL14434166 | 0.82 | MAPT (0.50) | MAPTTDP1CHEK2CYP26A1RXRA | |
| SCHEMBL13341961 | 0.79 | CHRNA7 (0.41) | ALOX15CHEK2KMT2AMEN1 | |
| SCHEMBL6341269 | 0.79 | RECQL (0.60) | ALOX15MAPTRECQLFADS1PARP1 | |
| SCHEMBL5782815 | 0.75 | TP53 (0.45) | MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12022157 | 0.74 | ALDH1A1 (0.42) | MAPTTDP1KMT2AMEN1GAA | |
| SCHEMBL4288792 | 0.74 | MAPT (0.33) | ALOX15MAPTTDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339709-B1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-24 | — | — | EP | disclosed |
| EP-0977750-B1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-04 | — | — | EP | disclosed |
| US-7153958-B2 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-26 | — | — | US | disclosed |
| US-20040034218-A1 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-19 | — | — | US | disclosed |
| US-6358961-B1 | ADMINISTERING QUINAZOLINE DERIVATIVE FOR INHIBITING TUMOR GROWTH IN MAMMALS | JANNSEN-CILAG S.A. (FR) | 2002-03-19 | — | — | US | disclosed |
| US-6177432-B1 | ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS | JANSSEN-CILAG S.A. (FR) | 2001-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034218-A1 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | FNTA, FNTB, RCE1 | ALOX15 1923/4885MAPT 3857/4885TDP1 3431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.