Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517123 | 0.87 | MAPK14 (0.51) | MAPK14ALDH1A1KDM4EMAPTP2RX7 | |
| SCHEMBL4504766 | 0.83 | MAPK14 (0.40) | MAPK14ALDH1A1KDM4EMAPTP2RX7 | |
| SCHEMBL4507481 | 0.81 | MAPK14 (0.46) | MAPK14ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL4514436 | 0.76 | MAPK14 (0.52) | MAPK14ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL13678557 | 0.76 | MAPK14 (0.46) | MAPK14ALDH1A1 | |
| SCHEMBL4510899 | 0.74 | P2RX7 (0.42) | ALDH1A1KDM4EMAPTP2RX7LMNA | |
| SCHEMBL14435515 | 0.74 | MAPK14 (0.54) | MAPK14ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL4506734 | 0.73 | MAPK14 (0.41) | MAPK14ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL13678553 | 0.73 | MAPK14 (0.53) | MAPK14ALDH1A1 | |
| SCHEMBL4505881 | 0.72 | MAPK14 (0.55) | MAPK14LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007091176-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |