Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 2/20 | 0.46 |
| ▸ | FPR3 | P25089 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431088 | 0.90 | HDAC8 (0.52) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435563 | 0.86 | HDAC8 (0.48) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713297 | 0.84 | HDAC8 (0.51) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL13002996 | 0.82 | HDAC8 (0.46) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435595 | 0.80 | AKT1 (0.45) | AKT1MC4ROPRK1 | |
| SCHEMBL12713306 | 0.80 | HDAC8 (0.48) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4778471 | 0.79 | HDAC8 (0.58) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713158 | 0.79 | MC4R (0.47) | MC4RFPR3FPR2EPHX2 | |
| SCHEMBL14436414 | 0.78 | UGCG (0.43) | HDAC8MC4RFPR3FPR2EPHX2 | |
| SCHEMBL14435946 | 0.77 | HDAC8 (0.44) | HDAC8HDAC1HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096186-A1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2007-08-30 | — | — | WO | disclosed |