Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12713306 | 0.95 | HDAC8 (0.48) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435584 | 0.90 | HRH1 (0.47) | KDM4ENPC1RAB9ASMN1; SMN2AKT1 | |
| SCHEMBL12713297 | 0.88 | HDAC8 (0.51) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435946 | 0.88 | HDAC8 (0.44) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713290 | 0.86 | ADAM17 (0.41) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713270 | 0.86 | HTR7 (0.39) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713110 | 0.86 | CALCA (0.46) | KDM4ENPC1RAB9ASMN1; SMN2F10 | |
| SCHEMBL14431088 | 0.86 | HDAC8 (0.52) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713089 | 0.85 | CALCA (0.45) | KDM4ENPC1RAB9ASMN1; SMN2F10 | |
| SCHEMBL14435974 | 0.84 | AKT1 (0.46) | AKT1AKT2AKT3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004604-B1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS CH (CH) | 2010-12-01 | — | — | EP | disclosed |
| WO-2007096186-A1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2007-08-30 | — | — | WO | disclosed |