Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 8/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.43 |
| ▸ | DPP4 | P27487 | 3/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | MC1R | Q01726 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431134 | 0.93 | AKT1 (0.46) | AKT1DPP7DPP4FAPDPP8 | |
| SCHEMBL14431088 | 0.90 | HDAC8 (0.52) | AKT1DPP4MC4R | |
| SCHEMBL14435584 | 0.85 | HRH1 (0.47) | AKT1DPP7DPP4FAPDPP8 | |
| SCHEMBL14435563 | 0.84 | HDAC8 (0.48) | AKT1DPP4MC4R | |
| SCHEMBL14435259 | 0.83 | AKT1 (0.43) | AKT1DPP7DPP4FAPDPP8 | |
| SCHEMBL14435265 | 0.83 | AKT1 (0.43) | AKT1DPP7DPP4FAPDPP8 | |
| SCHEMBL14435974 | 0.83 | AKT1 (0.46) | AKT1DPP7DPP4FAPDPP8 | |
| SCHEMBL14431138 | 0.81 | HRH2 (0.48) | MC4RHRH2HRH1 | |
| SCHEMBL14435216 | 0.80 | HDAC8 (0.54) | AKT1MC4ROPRK1 | |
| SCHEMBL14435602 | 0.79 | AKT1 (0.47) | AKT1DPP7DPP4FAPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096186-A1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2007-08-30 | — | — | WO | disclosed |