Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.43 |
| ▸ | MC4R | P32245 | 10/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.36 |
| ▸ | MC5R | P33032 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435238 | 1.00 | ADAM17 (0.43) | ADAM17ADAMTS5MC4RAKT1AKT2 | |
| SCHEMBL14436415 | 0.92 | HDAC8 (0.46) | ADAM17ADAMTS5MC4RAKT1AKT2 | |
| SCHEMBL14436419 | 0.92 | HDAC8 (0.46) | ADAM17ADAMTS5MC4RAKT1AKT2 | |
| SCHEMBL14435251 | 0.90 | ADAM17 (0.39) | ADAM17ADAMTS5MC4RAKT1AKT2 | |
| SCHEMBL14435281 | 0.90 | ADAM17 (0.39) | ADAM17ADAMTS5MC4RAKT1AKT2 | |
| SCHEMBL14435977 | 0.88 | ADAM17 (0.45) | ADAM17ADAMTS5AKT1 | |
| SCHEMBL14435975 | 0.88 | ADAM17 (0.45) | ADAM17ADAMTS5AKT1 | |
| SCHEMBL12713270 | 0.85 | HTR7 (0.39) | ADAM17ADAMTS5MC4RAKT1AKT2 | |
| SCHEMBL14435274 | 0.85 | PROKR1 (0.41) | ADAM17ADAMTS5MC4RAKT1AKT2 | |
| SCHEMBL14435240 | 0.84 | ADAM17 (0.42) | ADAM17ADAMTS5MC4RHDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096186-A1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2007-08-30 | — | — | WO | disclosed |