Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | CFTR | P13569 | 2/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435382 | 0.90 | KCNA5 (0.39) | SMN1; SMN2SLC6A3KCNA5PTGER2 | |
| SCHEMBL4461864 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2SLC6A3CFTRGOPCSLC6A2 | |
| SCHEMBL14435380 | 0.83 | ROCK2 (0.36) | SLC6A3KCNA5KDM4ECYP2D6 | |
| SCHEMBL4453045 | 0.81 | NR3C2 (0.39) | SMN1; SMN2SLC6A3CFTRGOPCSLC6A2 | |
| SCHEMBL13971398 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2SLC6A3CFTRGOPCSLC6A2 | |
| SCHEMBL4466427 | 0.79 | KCNA5 (0.51) | SLC6A3CFTRGOPCSLC6A2SLC6A4 | |
| SCHEMBL4468137 | 0.79 | GAA (0.36) | SMN1; SMN2SLC6A3CFTRGOPCSLC6A2 | |
| SCHEMBL14435433 | 0.77 | CFTR (0.42) | SMN1; SMN2SLC6A3CFTRGOPCSLC6A2 | |
| SCHEMBL13957483 | 0.77 | CFTR (0.42) | SMN1; SMN2SLC6A3CFTRGOPCSLC6A2 | |
| SCHEMBL4462104 | 0.77 | CFTR (0.42) | SMN1; SMN2SLC6A3CFTRGOPCSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |