SCHEMBL14435586

SCHEMBL14435586

COc1c(O)c(O)c(F)c(F)c1F

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.33
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20274462 0.92 TDP1 (0.35) TDP1CYP3A4MAPTPDE4APDE4B
SCHEMBL4048269 0.84 HSD17B10 (0.33) TDP1CYP3A4MAPTPDE4APDE4B
SCHEMBL11129794 0.83 TDP1 (0.36) TDP1CYP3A4MAPTPDE4APDE4B
SCHEMBL21103403 0.77 HSD17B10 (0.40) TDP1CYP3A4MAPTPDE4APDE4B
SCHEMBL4951694 0.76 HSD17B10 (0.35) TDP1
SCHEMBL182607 0.76 HSD17B10 (0.40) TDP1
SCHEMBL5586772 0.73 KMT2A (0.45) TDP1CYP3A4MAPT
SCHEMBL28796108 0.73 HSD17B10 (0.38) TDP1
SCHEMBL27598716 0.73 HSD17B10 (0.31) TDP1
SCHEMBL27341083 0.73 PTPN1 (0.40) TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007086535-A1 PRODUCTION METHOD OF OPTICAL TRANSMISSION MEDIUM FUJIFILM CORPORATION (JP) 2007-08-02 WO disclosed