SCHEMBL14440328

SCHEMBL14440328

CN1C(=O)c2c(c3c4ccccc4n(C4C=C[C@@H](O)C4)c3c3[nH]c4ccc(Br)cc4c23)C1=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 6/20 0.53
CDK4 P11802 3/20 0.44
CCND1 P24385 3/20 0.44
CAMK2B Q13554 1/20 0.44
CAMK2G Q13555 1/20 0.44
CAMK2D Q13557 1/20 0.44
CAMK2A Q9UQM7 1/20 0.44
PRKCQ Q04759 7/20 0.42
TOP1 P11387 2/20 0.42
CCNB2 O95067 1/20 0.41
CCNE2 O96020 1/20 0.41
CDK1 P06493 1/20 0.41
CCNB1 P14635 1/20 0.41
CCNE1 P24864 1/20 0.41
CDK2 P24941 1/20 0.41
CCNB3 Q8WWL7 1/20 0.41
ROCK2 O75116 7/20 0.41
PRKD3 O94806 2/20 0.37
PRKCG P05129 2/20 0.37
PRKCB P05771 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14440332 0.93 PRKCA (0.53) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL8351770 0.91 PRKCA (0.62) PRKCACDK4CCND1PRKCQCCNE2
SCHEMBL14440329 0.89 PRKCQ (0.44) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL8354981 0.89 CDK4 (0.55) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL14440432 0.84 TOP1 (0.49) PRKCACDK4CCND1PRKCQTOP1
SCHEMBL14440333 0.82 CDK4 (0.55) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL8354170 0.82 PRKCQ (0.44) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL8353619 0.80 PRKCA (0.58) PRKCACDK4CCND1PRKCQCCNE2
SCHEMBL8351539 0.80 PRKCQ (0.61) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL14440428 0.80 PRKCQ (0.61) PRKCACDK4CCND1CAMK2BCAMK2G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7262215-B2 N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors NAD AG (DE) 2007-08-28 US disclosed
US-7262215-B2 N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors NAD AG (DE) 2007-08-28 US disclosed